Supporting Gut Integrity With Effective Probiotics
Webinar EXECUTIVE SUMMARY
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Key Takeaways
Meet the Speakers
Probiotics Build Optimal Gut Performance
Probiotics Work by Enhancing the Intestinal Surface Area
Different Bacillus Strains Have Different Effects
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Probiotics “Support Normal”
Different Microorganisms Can Help—or Hurt—the Gut
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sponsored by:
Keith Kinsley, Technical Service Manager – Swine, Chr. Hansen
Moderated by Sarah Muirhead, Editor & Managing Director, Farm Progress – Livestock
Featuring:
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Eubiosis describes naturally occurring, consistent, and balanced functionality within the intestinal microbiome environment. Dysbiosis describes an imbalance of the microbiota, potentially favoring a pro-inflammatory infection or pathogenic organism development. Dysbiosis can lead to damage to the intestine and its integrity. Microorganism interactions within the microbiota influence changes to the microbiotic state, shifting it toward either eubiotic or dysbiotic. Microorganisms have quorum-sensing activities, meaning, as the concentration of bacteria increases, the associated increase in chemical signaling calls more like-organisms to themselves, eventually gathering in enough number to activate control of specific gene expression. In the case of potentially harmful bacteria, this can lead to toxin production and organized cell death that results in significant damage to the intestinal surface. However, the same concentration of Bacillus-based probiotics can have the opposite effect, establishing a protective biofilm to blunt infection and GIT damage.
Key Takeaway
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“We have 52 company restaurants, making us the largest operator of the restaurant brand. So, we are right there next to the franchisee. We know exactly what it takes to run them and what it takes to build them and what the challenges are, be they labor or food or whatever.”
- Scott Deviney, CEO, Chicken Salad Chick
Depending on the bacteria, growth can support increased damage or increase protection of the gut.
"Whether it be directly attached to, or forming communicating layers with . . . other biofilms, that can serve as a protective layer to that intestinal surface. These Bacillus-based probiotics can interact with one another, communicate, and organize in a protective manner."
- Keith Kinsley, Technical Service Manager – Swine, Chr. Hansen
Keith Kinsley on Probiotics Supporting Eubiosis
What are probiotics? They are live microorganisms used to benefit host health. These live—or active—microorganisms are differentiated from general feed additives by their drive to survive and reproduce. The natural capabilities of Bacillus-based probiotics can be leveraged in the digestive system to improve the health of production animals. Common results of probiotics in feed are:
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Bacillus-based probiotics stimulate, support, and strengthen intestinal integrity.
“If we don't support that gut integrity and help it to operate as it should, we really probably shouldn't count on anything else working as it should, either.”
A normal absorption of nutrients that supports normal rates of growth or efficiencies of that feed conversion. Normal intestinal health and use of nutrients that support normal health status and group morbidity.
Stimulating, supporting, and strengthening intestinal integrity are all related. Modes of action are based on active cells in the digestive system that work to reduce digestive upsets and support optimal performance.
Modes of Action of Probiotics
As living organisms, Bacillus-based probiotics are unique in their capabilities to perform many varied modes of action in a responsive manner to their environment, substrates, and other microbial encounters. Bacillus germination begins in the stomach, continuing through the gastrointestinal tract (GIT). As the probiotics move through the small intestine and colon, they multiply and grow, enhancing the intestinal surface area by increasing ileal villi height. Healthy, protruding villi will offer significantly higher absorptive capacity than will more blunted villi. By reducing villus tip damage, the epithelial barrier is improved, making it less susceptible to pathogen invasion and increasing absorption.
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Bacillus-based probiotics multiply and grow throughout the gastrointestinal tract.
“It’s a fairly reasonable way to get new guests in your restaurant, partly because third-party delivery is bringing them there.”
"It's impossible to believe that if we have a scenario where leaky gut is occurring, that we're benefiting nutrient absorption in a positive manner."
Keith Kinsley on Probiotics Enhancing Intestinal Surface Area
Chr. Hansen employs a rigorous screening process on candidate probiotic organisms through evaluation of probiotic modes of action and undertaking multiple measures and assessments before they are utilized in any animal directly. Screening of an optimal strain for a Bacillus-based probiotic can be partially accomplished by:
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How Chr. Hansen evaluates the candidate organism for potential probiotic benefits.
Evaluating probiotic to potentially harmful microbe antagonisms that are present between Bacilli and common pathogens of the target animal populations. Simulation (in vitro) of probiotic organism exclusion of population-specific potentially harmful bacterial species. Studying the interaction and stimulating capability of candidate Bacillus organisms towards mucin/mucus production.
One goal of proper screening and selection of probiotics is to assist in maintaining a sturdy intestinal barrier by helping to support separation of luminal and bloodstream spaces, limiting indiscriminate transfer of harmful organisms, toxins and electrolytes, and helping to maintain proper function.
Keith Kinsley on Measuring Permeability with TEER Assay
There is a saying at Chr. Hansen: Supporting normal. However, this does not mean working toward the average. Instead, "Supporting normal" at Chr. Hansen means helping animals reach or approach their optimal potential. Effective probiotics provide the ability to do just that. In several controlled studies, Bacillus-based probiotics were found to:
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Chr. Hansen probiotics optimize performance across various stages.
"As we look at these axes and how they communicate with one another . . . we can further benefit these animals in these populations through . . . helping to stimulate, support, and strengthen gut integrity, but also the secondary benefits that would occur through that supporting process."
Positively shift the mean ending weight of pigs after severe challenge with PRRS Decrease weight loss in sows during the lactation period Increased litter weaning weight
Studies where Bacillus-based probiotics are fed in broilers and calves have similarly demonstrated beneficial intestinal surface area development. Additionally, feeding of Bacillus- based probiotics have shown beneficial communicating stimulation links between other organ systems: gut-lung and gut-brain axes.
Keith Kinsley
Technical Service Manager – Swine, Chr. Hansen
Keith received a DVM from the U of MN in 2004. Spent ten years of private practice and research associate experience servicing the swine industry and broader pharmaceutical community. Then he has spent 10 years, as a technical service manager for swine while in his 3rd year with Christian Hansen.
Sarah Muirhead - Moderator
Editor & Managing Director, Farm Progress – Livestock
Patrick Quirk
Vice President & General Manager, Vertiv
Patrick Quirk directs strategy for our global embedded firmware operations and now leads converged systems business. Prior to Vertiv, he served in leadership roles for telecommunications and semiconductor technology companies in the US and Europe.
Speakers
servicing the swine industry and broader pharmaceutical community. Then he has spent 10 years, as a technical service manager for swine while in his 3rd year with Christian Hansen.
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At times it is difficult to separate probiotics from feed additives that support similar modes of action. As living organisms, Bacillus-based probiotics are unique in their capabilities to perform many varied modes of action in a responsive manner to their environment, substrates, and other microbial encounters. While Bacilli utilize theses modes of action to compete and forage from their surroundings, the host organism can benefit in multiple ways from these activities. Stimulation, supporting, and strengthening gut integrity is one such mechanism by which the host is benefitted.
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